![]() Submit only on articles published within 6 months of issue date.(Exception: original author replies can include all original authors of the article) Submissions should not have more than 5 authors.Reference 1 must be the article on which you are commenting. Submissions must be You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid If you are responding to a comment that was written about an article you originally authored: Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment. You must have updated your disclosures within six months: If you are uploading a letter concerning an article: Copyright © 2014 by AAN Enterprises, Inc.Khan has received research funding from NIH, NINDS, National Multiple Sclerosis Society, Teva Neuroscience, Biogen Idec, Genzyme Corporation, Roche, and Novartis. Khan has received personal compensation for activities with Biogen Idec, Genzyme Corporation, Novartis, and Teva Neuroscience. ![]() Caon has received personal compensation for activities with Teva Neuroscience, Novartis, Genzyme Inc., and Biogen Idec. Tselis has recieved research support from Teva Neuroscience and Biogenic Idec. Bernitsas has received personal compensation for activities with Biogen Idec, Novartis, and Teva Neuroscience. Larger studies are warranted to confirm our findings and validate this observation.ĭisclosure: Dr. Of the non-MS group (CAID), 98.1% were correctly classified.ĬONCLUSIONS: 4.5 or greater isolated CSF OCB detected by IEF may be a useful clinical diagnostic observation that differentiates MS from other disorders also presenting with CSF OCB and clinical mimickers of MS. Isolated CSF OCB of 4.5 or greater, had sensitivity of 0.839 and specificity of 0.981 in predicting MS. ROC curve analysis showed diagnostic discrimination of 0.985. Simple logistic regression showed both CSF OCB and isolated CSF OCB differentiated MS from other CAID, with odds ratio of 4.1 (p<0.0001) and 7.8 (p=0.0006), respectively. Mean number of isolated CSF OCB was 7.8 and 1.2 in the MS and other CAID groups respectively (p<0.0001). Mean number of CSF OCB was 8.5 and 1.7, in MS and other CAID groups, respectively (p<0.0001). Mean age in MS group was 36.9 years and other CAID was 38.6 years. Other CAID included vasculitis (n=6), Sjogren’s (n=7), sarcoidosis (n=30), lupus (n=6), and anti-phospholipid antibody syndrome (n=4), all with definite CNS involvement. RESULTS: 56 patients with MS and 53 patients with other CAID were included in the study. ![]() All patients met the established diagnostic criteria for each disease state, supported by tissue biopsy when indicated. METHODS: This was a retrospective study of patients with MS and other CAID, who underwent CSF analysis between 20. since 2004, few studies have examined the utility of CSF IEF in distinguishing multiple sclerosis from other CAID. IEF combined with IgG immunoblotting has been to shown to have greater sensitivity in detecting CSF oligoclonal bands than agarose gel electrophoresis. OBJECTIVE: To examine the presence of CSF oligoclonal bands (OCB) detected by Isoelectric focusing (IEF) in patients with MS and other CNS autoimmune disorders.īACKGROUND: CSF OCB are one of immunopathologic features of CSF in patients with MS and other CNS autoimmune disorders (CAID).
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